IL-33, Imprimatur of Adipocyte Thermogenesis
نویسنده
چکیده
Chawla and colleagues find that interleukin-33 is a critical controller of brown and beige adipocyte thermogenesis. Its primary impact is on the splicing of transcripts encoding uncoupling protein-1, resulting in uncoupled respiration and effective heat generation. Interleukin-33 acts perinatally to ensure adaptive thermogenesis lifelong.
منابع مشابه
Perinatal Licensing of Thermogenesis by IL-33 and ST2
For placental mammals, the transition from the in utero maternal environment to postnatal life requires the activation of thermogenesis to maintain their core temperature. This is primarily accomplished by induction of uncoupling protein 1 (UCP1) in brown and beige adipocytes, the principal sites for uncoupled respiration. Despite its importance, how placental mammals license their thermogenic ...
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عنوان ژورنال:
- Cell
دوره 166 شماره
صفحات -
تاریخ انتشار 2016